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Xylazine can be swallowed, inhaled, smoked, snorted, or injected into the muscle or vein. There is no information on vaping. It has rapid onset within minutes and can last 8 hours or longer depending upon the dose, way it was taken, and whether it was mixed with an opioid or other drug.
In recent years, xylazine, which is commonly known as “tranq,” has helped to accelerate the already-deadly U.S. drug crisis. The drug is increasingly being mixed into illicit opioids like fentanyl, contributing to overdose spikes across the country, particularly in northeastern cities like Philadelphia and New York.
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