About Drug Use

Chronic use of drugs of abuse produces changes and cellular adaptations in neurons located in the VTA (Ventral Tegmental Area) of the brain, which is part of the dopamine-mediated reward pathway. Nevertheless, These adaptations are mediated by BDNF (brain-derived neurotrophic factor) and are associated with the aversive withdrawal motivation that leads to a drug-dependent state. Furthermore, there is growing evidence that suggests that 5-HT2A receptor signaling can regulate the expression of BDNF in the brain. Moreover, Both 5-HT and TrkB signaling are involved in modulating long-term neuronal survival and plasticity but it is still unknown if these effects occur via a direct 5HT2A interaction or downstream interactions between 5HT2A.